Image: Splicing activation

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Description: Generalized model of splicing activation. Splicing activator proteins (mostly SR proteins) bind to splicing enhancers in exons (ESE) and introns (ISE). They assist in the binding of U1 snRNP to the donor site and of U2AFs and U2 snRNP to the acceptor site and branch point. Information from: Black, Douglas L. (2003). "Mechanisms of alternative pre-messenger RNA splicing". Annual Reviews of Biochemistry 72 (1): 291-336. Wang, Z; Burge, Cb (May 2008). "Splicing regulation: from a parts list of regulatory elements to an integrated splicing code" (Free full text). RNA (New York, N.Y.) 14 (5): 802–13. doi:10.1261/rna.876308. ISSN 1355-8382. PMID 18369186. PMC: 2327353.
Title: Splicing activation
Credit: Own work
Author: Agathman
Usage Terms: Creative Commons Attribution-Share Alike 3.0
License: CC BY-SA 3.0
License Link: http://creativecommons.org/licenses/by-sa/3.0
Attribution Required?: Yes

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Alternative splicing

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