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Image: Replication-transcription complex for Coronaviruses cropped

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Description: Model of the replicase-transcriptase complex of a coronavirus. Illustration shows how the RNA sliding clamp for processivity and primase domain for priming (nsp7 and nsp8 – green/orange) could assemble on viral dsRNA and interact with the putative multi-subunit coronavirus polymerase complex consisting of RdRp for replication (nsp12 – red), ExoN for proofreading (nsp14 – dark blue), and ExoN cofactor (nsp10 – yellow). To initiate replication-transcription there is a short (∼6 n.t.) primer generated by the non-canonical RdRp activity of nsp8 (I and II). Binding of ssRNA by RNA binding proteins (nsp9 – light blue) to avoid secondary structure is also shown. A helicase to unwind RNA (nsp13) is not shown downstream.
Title: Replication-transcription complex for Coronaviruses cropped
Credit: This file is a derivative work of an image by Everett Clinton Smith and Mark R. Denison https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003760
Author: Guest2625
Usage Terms: Creative Commons Attribution-Share Alike 4.0
License: CC BY-SA 4.0
License Link: https://creativecommons.org/licenses/by-sa/4.0
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