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Image: Proteolytic activation of SREBF-controlled lipid biosynthesis

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Description: SREBF-1 is synthesized as inactive precursors in ER, where it resides in a complex with SCAP, a sterol sensor, and INSIG-1. Upon activation, when sterol levels are low, SCAP undergoes a conformational change and is released from INSIG. SCAP assists the transport of the precursor SREBF-1 to the Golgi apparatus followed by a two-step proteolytic cleavage thus releasing a transcriptionally active N-terminal domain. This domain is subsequently translocated to the nucleus, resulting in the expression of SREBF target genes.
Title: Proteolytic activation of SREBF-controlled lipid biosynthesis
Credit: Own work
Author: VeraOli
Usage Terms: Creative Commons Attribution-Share Alike 3.0
License: CC BY-SA 3.0
License Link: http://creativecommons.org/licenses/by-sa/3.0
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