Image: Lead-exposed rat hippocampi

Description: accompanying text reads, "Representative electron micrographs of coronal sections of the rat hippocampus are shown. (A, C, and E) control hippocampus. (B, D and F) lead-exposed hippocampus in rats at weaning that were treated with 0.2% lead acetate during the gestational and lactational periods as described. Abnormal appearance of neurons including irregular shaped nucleus, swollen mitochondria, often vacuolated with disrupted cristae, a large quantity of heterochromatin collected inside the nucleus, demyelination or shrinkage, and denaturation of the myelin sheath were observed. These findings suggest that hippocampal ultrastructures were injured by lead exposure during the early stage of life. Scale bar = 1 μm. NN: normal nucleus; IN: irregular nucleus; SM: swollen mitochondria; VM: vacuolated mitochondria; NM: normal mitochondria; H: heterochromatin; DMS: denaturation of myelin sheath." (only A and B are used in this modification of the image).
Title: Lead-exposed rat hippocampi
Credit: http://www.jnrbm.com/content/8/1/5 Xu, J; Yan, Hc; Yang, B; Tong, Ls; Zou, Yx; Tian, Y (Apr 2009). "Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats" (Free full text). Journal of negative results in biomedicine 8: 5. doi:10.1186/1477-5751-8-5. PMID 19374778. PMC: 2674876. http://www.jnrbm.com/content/8//5.
Author: Xu, J; Yan, Hc; Yang, B; Tong, Ls; Zou, Yx; Tian, Y (modified 9/1/09 by user:delldot)
Permission: This file is licensed under the Creative Commons Attribution 2.0 Generic license. You are free: to share – to copy, distribute and transmit the work to remix – to adapt the work Under the following conditions: attribution – You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work). http://creativecommons.org/licenses/by/2.0 CC BY 2.0 Creative Commons Attribution 2.0 truetrue
Usage Terms: Creative Commons Attribution 2.0
License: CC BY 2.0
License Link: http://creativecommons.org/licenses/by/2.0
Attribution Required?: Yes