- Old Post Office, 300 East Main Street, 30°00′15″N 91°49′00″W / 30.00411°N 91.81656°W / 30.00411; -91.81656 (Old Post Office), built c.1903. Also listed in East Main Street Historic District.
- Pascal Building, 223 East Main Street, 30°00′17″N 91°48′59″W / 30.00459°N 91.81647°W / 30.00459; -91.81647 (Pascal Building), built 1889. Also individually listed.
- Leblanc & Broussard Ford Dealership, 221 East Main Street, 30°00′17″N 91°49′00″W / 30.00466°N 91.81656°W / 30.00466; -91.81656 (Leblanc & Broussard Ford Dealership), built c.1912.
- Leblanc & Broussard Service Department Warehouse, 221½ East Main Street, 30°00′18″N 91°48′59″W / 30.00496°N 91.81634°W / 30.00496; -91.81634 (Leblanc & Broussard Service Department Warehouse), built 1931.
- Davis Building, 133 East Main Street, 30°00′18″N 91°49′02″W / 30.00508°N 91.81728°W / 30.00508; -91.81728 (Davis Building), built 1892.
- Bayou Teche Museum, 131 East Main Street, 30°00′19″N 91°49′02″W / 30.0052°N 91.81727°W / 30.0052; -91.81727 (Bayou Teche Museum), built 1929-30.
- Evangeline Theater, 129 East Main Street, 30°00′19″N 91°49′02″W / 30.00528°N 91.81736°W / 30.00528; -91.81736 (Evangeline Theater), built 1929-30. Also individually listed.
- Crystal Image, 115 East Main Street, 30°00′19″N 91°49′02″W / 30.00528°N 91.81736°W / 30.00528; -91.81736 (Crystal Image).
- Crystal Image, 115 East Main Street, 30°00′20″N 91°49′04″W / 30.00561°N 91.81773°W / 30.00561; -91.81773 (Crystal Image).
- Provost's Café, 113 East Main Street, 30°00′20″N 91°49′04″W / 30.00567°N 91.81779°W / 30.00567; -91.81779 (Provost's Café). Also known as Armand's and Clementine's Fine Dining.
- Building at 111 East Main Street, 30°00′21″N 91°49′04″W / 30.00573°N 91.81784°W / 30.00573; -91.81784 (111 East Main Street).
- Building at 109 East Main Street, 30°00′21″N 91°49′05″W / 30.00576°N 91.81792°W / 30.00576; -91.81792 (109 East Main Street).
- Coleman Building, 105 East Main Street, 30°00′21″N 91°49′05″W / 30.00587°N 91.81803°W / 30.00587; -91.81803 (Coleman Building).
- DeRouen Financial, 103 East Main Street, 30°00′22″N 91°49′05″W / 30.00598°N 91.81799°W / 30.00598; -91.81799 (DeRouen Financial).
- Renoudet Building, 101 East Main Street, 30°00′22″N 91°49′05″W / 30.00604°N 91.81803°W / 30.00604; -91.81803 (Renoudet Building).
- Building at 144 West Main Street, 30°00′25″N 91°49′09″W / 30.00705°N 91.81912°W / 30.00705; -91.81912 (144 West Main Street). Built 1941.
- Building at 144A West Main Street, 30°00′26″N 91°49′08″W / 30.00717°N 91.81895°W / 30.00717; -91.81895 (144A West Main Street). Built 1941.
- McMahon Furniture Company, 150 West Main Street, 30°00′26″N 91°49′09″W / 30.00727°N 91.81927°W / 30.00727; -91.81927 (McMahon Furniture Company). Built 1890.
- Satterfield Building, 152 West Main Street, 30°00′26″N 91°49′10″W / 30.00734°N 91.81934°W / 30.00734; -91.81934 (Satterfield Building). Built 1881.
- Chevron (Gulf) Service Station, 200 West Main Street, 30°00′27″N 91°49′10″W / 30.0076°N 91.81957°W / 30.0076; -91.81957 (Chevron (Gulf) Service Station). Built 1927.
- Riviere's Jewelry Store, 214 West Main Street, 30°00′28″N 91°49′11″W / 30.00764°N 91.81969°W / 30.00764; -91.81969 (Riviere's Jewelry Store). Built 1940s.
- Slim's News Stand, 216 West Main Street, 30°00′28″N 91°49′11″W / 30.00768°N 91.81972°W / 30.00768; -91.81972 (Slim's News Stand). Built 1940s.
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- Iberia Steam Laundry, 220 West Main Street, 30°00′28″N 91°49′11″W / 30.00777°N 91.81978°W / 30.00777; -91.81978 (Iberia Steam Laundry).
- Steinberg Building, 232 West Main Street, 30°00′29″N 91°49′12″W / 30.00812°N 91.8201°W / 30.00812; -91.8201 (Steinberg Building). Built c.1880.
- American Department Store, 254 West Main Street, 30°00′31″N 91°49′14″W / 30.00858°N 91.82046°W / 30.00858; -91.82046 (American Department Store). Built 1950s.
- Hebert's Hotel, 213-225 West Main Street, 30°00′28″N 91°49′13″W / 30.00767°N 91.82024°W / 30.00767; -91.82024 (Hebert's Hotel).
- John R. Taylor Drugstore, 145 West Main Street, 30°00′25″N 91°49′11″W / 30.00695°N 91.81959°W / 30.00695; -91.81959 (John R. Taylor Drugstore). Built 1907. Also individually listed.
- Bayou Art Gallery, 143 West Main Street, 30°00′25″N 91°49′10″W / 30.00682°N 91.81941°W / 30.00682; -91.81941 (Bayou Art Gallery). Built 1870s.
- Armentor's Jewelry Store, 137 West Main Street, 30°00′24″N 91°49′10″W / 30.00671°N 91.81934°W / 30.00671; -91.81934 (Armentor's Jewelry Store).
- Abdalla's Department Store, 131 West Main Street, 30°00′23″N 91°49′10″W / 30.00652°N 91.81941°W / 30.00652; -91.81941 (Abdalla's Department Store). Built 1950s-1960s.
- Napoleon's on the Teche, 127 West Main Street, 30°00′23″N 91°49′10″W / 30.00644°N 91.81931°W / 30.00644; -91.81931 (Napoleon's on the Teche). Built 1950s-1960s.
- Abdalla's Department Store Building #3, 131A West Main Street, 30°00′23″N 91°49′09″W / 30.00638°N 91.81923°W / 30.00638; -91.81923 (Abdalla's Department Store Building #3). Built 1950s-1960s.
- People's National Bank, 119 West Main Street, 30°00′23″N 91°49′08″W / 30.00631°N 91.81897°W / 30.00631; -91.81897 (People's National Bank). Built 1911. Also individually listed.
- Building at 109 West Main Street, 30°00′22″N 91°49′08″W / 30.00609°N 91.81884°W / 30.00609; -91.81884 (109 West Main Street).
- Model Company, 107 West Main Street, 30°00′22″N 91°49′08″W / 30.00603°N 91.81876°W / 30.00603; -91.81876 (Model Company).
- Building at 105 West Main Street, 30°00′21″N 91°49′07″W / 30.00597°N 91.81871°W / 30.00597; -91.81871 (105 West Main Street).
- Gougenheim Building, 101 West Main Street, 30°00′21″N 91°49′07″W / 30.00588°N 91.81866°W / 30.00588; -91.81866 (Gougenheim Building). Built c.1893. Also known as Hugonin Building and Morgan & Lindsay.
- Bowab's, 102 East Main Street, 30°00′21″N 91°49′06″W / 30.00571°N 91.81846°W / 30.00571; -91.81846 (Bowab's). Built c.1893.
- Creims, 104 East Main Street, 30°00′20″N 91°49′06″W / 30.00566°N 91.8184°W / 30.00566; -91.8184 (Creims). Built c.1893.
- Babineaux's Shoes, 108 East Main Street, 30°00′20″N 91°49′06″W / 30.00554°N 91.81832°W / 30.00554; -91.81832 (Babineaux's Shoes).
- Ackal's Department Store, 110 East Main Street, 30°00′20″N 91°49′06″W / 30.00548°N 91.81827°W / 30.00548; -91.81827 (Ackal's Department Store).
- Wormser's Department Store, 112-116 East Main Street, 30°00′19″N 91°49′05″W / 30.00534°N 91.81816°W / 30.00534; -91.81816 (Wormser's Department Store). Built 1932. Also individually listed.
- Building at 120 East Main Street, 30°00′19″N 91°49′05″W / 30.00517°N 91.81803°W / 30.00517; -91.81803 (120 East Main Street). Built 1950s.
- Building at 122 East Main Street, 30°00′18″N 91°49′05″W / 30.00512°N 91.81797°W / 30.00512; -91.81797 (122 East Main Street). Built 1950s.
- Bazus Building, 210 East Main Street, 30°00′16″N 91°49′02″W / 30.00454°N 91.8172°W / 30.00454; -91.8172 (Bazus Building).
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